Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6XZRL)

Drug Name
SA-5845 Drug Info
Synonyms Carbon-11 labeled sigma opioid receptor ligands, Santen; FE-SA-4503; FE-SA-5845; Carbon-11-SA-4503; Carbon-11-SA-5845; 11C-SA-4503; 11C-SA-5845
Indication
Disease Entry ICD 11 Status REF
Central nervous system disease 8A04-8D87 Phase 1 [1]
Psychotic disorder 6A20-6A25 Preclinical [2]
Cross-matching ID
TTD Drug ID
DM6XZRL

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Opioid receptor sigma 1 (OPRS1) TT5TPI6 SGMR1_HUMAN Binder [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Opioid receptor sigma 1 (OPRS1) DTT SIGMAR1 7.092 5.716 5.411 6.434
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Central nervous system disease
ICD Disease Classification 8A04-8D87
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Opioid receptor sigma 1 (OPRS1) DTT SIGMAR1 2.77E-06 -0.12 -0.62
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study. J Nucl Med. 2004 Nov;45(11):1939-45.
2 Preclinical evaluation of [11C]SA4503: radiation dosimetry, in vivo selectivity and PET imaging of sigma1 receptors in the cat brain. Ann Nucl Med. 2000 Aug;14(4):285-92.