Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6Y2XK)

Drug Name

3-(1H-indol-3-yl)-N,N-dimethylpropan-1-amine Drug Info

Synonyms

NSC88622; 3-(1H-indol-3-yl)-N,N-dimethylpropan-1-amine; NSC-88622; 13117-35-6; CHEMBL360575; AC1Q3WPU; NCIStruc2_000554; NCIStruc1_000767; AC1L1D58; SCHEMBL3957606; N,N-DIMETHYLHOMOTRYPTAMINE; DTXSID00275574; ZINC393884; NCI88622; NCGC00013925; BDBM50162709; CCG-38332; AKOS024323101; MCULE-7123094039; NCGC00097034-01; NCGC00013925-02; NCI60_041964; [3-(1H-indol-3-yl)propyl]dimethylamine; [3-(1H-Indol-3-yl)-propyl]-dimethyl-amine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 52549
CAS Number: CAS 13117-35-6
TTD Drug ID: DM6Y2XK

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Serotonin transporter (SERT)	DTT	SLC6A4	6.278	5.469	6.075	6.966

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Serotonin transporter (SERT)	DTT	SLC6A4	8.76E-01	7.18E-05	6.19E-04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Conformationally restricted homotryptamines. Part 4: Heterocyclic and naphthyl analogs of a potent selective serotonin reuptake inhibitor. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5647-51.