Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM73S2C)

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apoptosis regulator Bcl-2 (BCL-2)	TTJGNVC	BCL2_HUMAN	Inhibitor	[1]
Apoptosis regulator Bcl-W (BCL-W)	TTQ79W8	B2CL2_HUMAN	Inhibitor	[1]
Apoptosis regulator Bcl-xL (BCL-xL)	TTU1E82	B2CL1_HUMAN	Inhibitor	[1]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	TTL53M6	MCL1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Apoptosis regulator Bcl-xL (BCL-xL)	DTT	BCL2L1	4.863	5.664	6.092	5.843
Apoptosis regulator Bcl-W (BCL-W)	DTT	BCL2L2	6.358	7.838	7.493	7.567
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	DTT	MCL1	7.695	6.404	5.954	6.82
Apoptosis regulator Bcl-2 (BCL-2)	DTT	BCL2	3.963	4.739	4.146	4.878

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Apoptosis regulator Bcl-xL (BCL-xL)	DTT	BCL2L1	7.28E-13	-0.55	-0.68
Apoptosis regulator Bcl-W (BCL-W)	DTT	BCL2L2	1.83E-48	-0.69	-1.67
Apoptosis regulator Bcl-2 (BCL-2)	DTT	BCL2	9.45E-01	1.35E-02	0.05

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178.