Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM74LZK)

Drug Name
Cromoglicate Drug Info
Synonyms Crolom (TN); Intal (TN); Nasalcrom (TN); Opticrom (TN); Optrex Allergy (TN); Prevalin (TN); Rynacrom (TN)
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Approved [1] , [2]
Allergic rhinitis CA08.0 Terminated [3]
Therapeutic Class
Antiasthmatic Agents
Cross-matching ID
PubChem CID
2882
ChEBI ID
CHEBI:59773
CAS Number
CAS 16110-51-3
TTD Drug ID
DM74LZK
ACDINA Drug ID
D00971

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Heat shock protein 90 alpha (HSP90A) TT78R5H HS90A_HUMAN Inhibitor [4]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Heat shock protein 90 alpha (HSP90A) DTT HSP90AA1 9.604 9.034 9.856 9.2
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Asthma
ICD Disease Classification CA23
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Heat shock protein 90 alpha (HSP90A) DTT HSP90AA1 3.96E-01 0.18 0.48
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7608).
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Sodium cromoglicate: an ineffective drug or meta-analysis misused Pharm Stat. 2007 Apr-Jun;6(2):123-37.
4 Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. Biochem J. 2003 Sep 1;374(Pt 2):433-41.