Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM79GRO)

Drug Name

Metamizole Drug Info

Synonyms

Dipyrone; dipyrone; Analgin; Metamizole sodium; Methampyrone; Novalgin; sulpyrine; 68-89-3; Neomelurbrin; Methylmelubrin; Algocalmin; Optalgin; Novalgetol; Sulpyrin; Pyralgin; Narone; Novaminsulfone; Novamidazophen; Nevralgina; Pharmalgine; Algopyrine; Farmolisina; Pyretin; Keypyrone; Analgine; Noveltex; Fevonil; Diprofarn; Dimethone; Alginodia; Pyrojec; Paralgin; Metilon; Metapyrin; Gifaril; Bonpyrin; Sulpin; Conmel; Barone; Neo-melubrine; Di-podil; Aminopyrine sodium sulfonate; Novaminsulfonum; Novaminsulfon; Metamizolum natricum

Indication

Disease Entry	ICD 11	Status	REF
Fever	MG26	Withdrawn from market	[1]
Pain	MG30-MG3Z	Withdrawn from market	[1]

Cross-matching ID

PubChem CID: 3111
ChEBI ID: CHEBI:62088
CAS Number: CAS 50567-35-6
TTD Drug ID: DM79GRO
INTEDE Drug ID: DR1037

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	Highest Status	REF
RNA cytidine acetyltransferase (hALP)	DEZV4AP	NAT10_HUMAN	Phase 4	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	6.09	7.747	6.04	7.023
RNA cytidine acetyltransferase (hALP)	DME	NAT10	7.324	6.95	7.289	7.155

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Fever

ICD Disease Classification

MG26

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin G/H synthase 1 (COX-1)	DTT	PTGS1	3.97E-03	0.16	0.43
RNA cytidine acetyltransferase (hALP)	DME	NAT10	8.46E-03	-4.02E-02	-2.28E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Mechanisms of action of paracetamol and related analgesics. Inflammopharmacology. 2003;11(4):401-13.
3	N-acetyltransferase 2 polymorphisms and susceptibility to infant leukemia with maternal exposure to dipyrone during pregnancy. Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3037-43.