Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7A50Z)

Drug Name

1-Cyclohexylidenethiosemicarbazide Drug Info

Synonyms

(cyclohexylideneamino)thiourea; Cyclohexanone thiosemicarbazone; 5351-77-9; Cyclohexanone, thiosemicarbazone; 1-Cyclohexylidenethiosemicarbazide; 2-cyclohexylidenehydrazinecarbothioamide; Hydrazinecarbothioamide, 2-cyclohexylidene-; CHEMBL510328; amino[(cyclohexylideneazamethyl)amino]methane-1-thione; AC1MD1GF; Thiosemicarbazonecyclohexanone; SCHEMBL941085; Thiosemicarbazone, cyclohexanone; NSC717; CTK1H1977; DTXSID20385240; NSC-717; MolPort-000-248-718; GYRDZVHNPFBIST-UHFFFAOYSA-N; HMS1577F04; ZINC5413245; SBB041170

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2829394
CAS Number: CAS 5351-77-9
TTD Drug ID: DM7A50Z

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosinase (TYR)	TTULVH8	TYRO_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tyrosinase (TYR)	DTT	TYR	5.959	5.711	5.973	4.912

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tyrosinase (TYR)	DTT	TYR	6.68E-04	2.54	1.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem. 2009 Apr;44(4):1773-8.