Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7AVGW)

Drug Name
Ocriplasmin Drug Info
Indication
Disease Entry ICD 11 Status REF
Symptomatic vitreomacular adhesion 9B8Z Approved [1]
Cross-matching ID
TTD Drug ID
DM7AVGW

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fibronectin (FN1) TTPJ921 FINC_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Fibronectin (FN1) DTT FN1 12.003 10.301 8.526 8.419
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Symptomatic vitreomacular adhesion
ICD Disease Classification 9B8Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Fibronectin (FN1) DTT FN1 4.24E-04 0.82 2.33
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7446).
2 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.