Details of the Drug

General Information of Drug (ID: DM7AVGW)

Drug Name
Ocriplasmin
Indication
Disease Entry ICD 11 Status REF
Symptomatic vitreomacular adhesion 9B8Z Approved [1]
Sequence
>heavy chain
APSFDCGKPQVEPKKCPGR
>light chain
VVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAH
QEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECF
ITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDS
GGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
ADMET Property
Metabolism
The drug is metabolized via protease inhibitor 2-antiplasmin or 2-macroglobulin []
Cross-matching ID
DrugBank ID
DB08888
TTD ID
D0Y7XG

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fibronectin (FN1) TTPJ921 FINC_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Symptomatic vitreomacular adhesion
ICD Disease Classification 9B8Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Fibronectin (FN1) DTT FN1 4.24E-04 0.82 2.33
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7446).
2 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.