Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7K5GD)

• Drug Name: Lutropin alfa Drug Info
• Synonyms: Luveris; Luveris (TN); Lutropin alfa (USAN/INN)

Indication

Disease Entry	ICD 11	Status	REF
Female infertility	GA31.Z	Approved	[1]

• Therapeutic Class: Fertility Agents
• Cross-matching ID: TTD Drug ID: DM7K5GD

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Luteinizing hormone receptor (LHCGR)	TT2O4W9	LSHR_HUMAN	Binder	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Luteinizing hormone receptor (LHCGR)	DTT	LHCGR	4.009	2.561	3.365	4.828

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Female infertility
• ICD Disease Classification: GA31.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Luteinizing hormone receptor (LHCGR)	DTT	LHCGR	3.55E-01	5.41E-04	4.54E-03

References

• [1] Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
• [2] Lutropin alfa. Drugs. 2008;68(11):1529-40.