Details of the Drug

General Information of Drug (ID: DM7K5GD)

Drug Name
Lutropin alfa
Synonyms Luveris; Luveris (TN); Lutropin alfa (USAN/INN)
Indication
Disease Entry ICD 11 Status REF
Female infertility GA31.Z Approved [1]
Therapeutic Class
Fertility Agents
Sequence
>Alpha chain
APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCC
VAKSYNRVTVMGGFKVENHTACHCSTCYYHKS
>Beta chain
SREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYR
DVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLF
L
ADMET Property
Half-life
The concentration or amount of drug in body reduced by one-half in 18 hours [2]
Metabolism
The drug is metabolized via renal []
Vd
The volume of distribution (Vd) of drug is 10-14 L []
Cross-matching ID
DrugBank ID
DB00044
TTD ID
D0Z2CM

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Luteinizing hormone receptor (LHCGR) TT2O4W9 LSHR_HUMAN Binder [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Female infertility
ICD Disease Classification GA31.Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Luteinizing hormone receptor (LHCGR) DTT LHCGR 3.55E-01 5.41E-04 4.54E-03
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
3 Lutropin alfa. Drugs. 2008;68(11):1529-40.