Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7OR48)

Drug Name
SAR-152954 Drug Info
Synonyms Histamine H3 antagonist (sleep disorder), Sanofi-aventis
Indication
Disease Entry ICD 11 Status REF
Sleep-wake disorder 7A00-7B2Z Discontinued in Phase 1 [1]
Cross-matching ID
TTD Drug ID
DM7OR48

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H3 receptor (H3R) TT9JNIC HRH3_HUMAN Antagonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Histamine H3 receptor (H3R) DTT HRH3 3.225 3.399 3.17 3.027
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Sleep-wake disorder
ICD Disease Classification 7A00-7B2Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Histamine H3 receptor (H3R) DTT HRH3 3.62E-02 -0.09 -0.22
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033674)
2 Clinical pipeline report, company report or official report of Sanofi.