Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7TX3D)

• Drug Name: CM-156 Drug Info
• Synonyms: Sigma opioid antagonists (addiction); Sigma opioid antagonists (addiction), University of Mississippi; 2(3H)-benzoxalones and 2(3H)-benzothiazolones (addiction), University of Mississippi

Indication

Disease Entry	ICD 11	Status	REF
Drug abuse	6C4G.1Z	Investigative	[1]

• Cross-matching ID: TTD Drug ID: DM7TX3D

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Opioid receptor sigma 1 (OPRS1)	TT5TPI6	SGMR1_HUMAN	Antagonist	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Opioid receptor sigma 1 (OPRS1)	DTT	SIGMAR1	7.092	5.716	5.411	6.434

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Drug abuse
• ICD Disease Classification: 6C4G.1Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Opioid receptor sigma 1 (OPRS1)	DTT	SIGMAR1	2.77E-06	-0.12	-0.62

References

• [1] Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.