Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7U02R)

Drug Name

(3-Chloro-phenyl)-piperazin-1-yl-methanone Drug Info

Synonyms

100939-90-0; 1-(3-chlorobenzoyl)piperazine; (3-chlorophenyl)(piperazin-1-yl)methanone; (3-Chloro-phenyl)-piperazin-1-yl-methanone; BAS 04443403; (3-Chlorophenyl)(1-piperazinyl)methanone; CHEMBL160911; Methanone, (3-chlorophenyl)-1-piperazinyl-; 1-[(3-chlorophenyl)carbonyl]piperazine; 3-chlorophenyl piperazinyl ketone; AC1LLWSU; AC1Q3I0G; TimTec1_008470; 4-(3-chlorobenzoyl)piperazine; SCHEMBL2733887; 1-(3-Chlorobenzoyl)-piperazine; CTK6H2326; DTXSID70360082; MolPort-000-163-293; FBTDRVSCKFZIQH-UHFFFAOYSA-N; ZINC782987

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1074765
CAS Number: CAS 100939-90-0
TTD Drug ID: DM7U02R

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]
5-HT 1D receptor (HTR1D)	TT6MSOK	5HT1D_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 1A receptor (HTR1A)	DTT	HTR1A	4.661	5.289	3.053	3.472
5-HT 1D receptor (HTR1D)	DTT	HTR1D	3.307	1.263	2.585	5.833

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1A receptor (HTR1A)	DTT	HTR1A	2.18E-01	-0.11	-0.51

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4.