Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7XER1)

Drug Name

N-phenyl-5,6-dip-tolylpyrazine-2-carboxamide Drug Info

Synonyms

CHEMBL225242; N-phenyl-5,6-dip-tolylpyrazine-2-carboxamide; SCHEMBL4450848; BDBM35881; 5,6-diaryl-pyrazine-2-amide derivative, 7b; 5,6-di-p-tolyl-pyrazine-2-carboxylic acid phenylamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10215860
TTD Drug ID: DM7XER1

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cannabinoid receptor 1 (CB1)	TT6OEDT	CNR1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Cannabinoid receptor 1 (CB1)	DTT	CNR1	2.907	4.667	2.982	3.678

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cannabinoid receptor 1 (CB1)	DTT	CNR1	5.59E-02	-0.22	-0.45
Cannabinoid receptor 1 (CB1)	DTT	CNR1	7.68E-01	-0.06	-0.46

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy... Bioorg Med Chem Lett. 2007 Jul 15;17(14):3978-82.