Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM86E2P)

Drug Name
Carboxylic acid derivative 1 Drug Info
Synonyms PMID28627961-Compound-37
Indication
Disease Entry ICD 11 Status REF
Angiogenesis disorder BE2Z Patented [1]
Neoplasm 2A00-2F9Z Patented [1]
Cross-matching ID
TTD Drug ID
DM86E2P

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin E synthase (PTGES) TTYLQ8V PTGES_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Prostaglandin E synthase (PTGES) DTT PTGES 4.289 5.498 5.489 5.794
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Angiogenesis disorder
ICD Disease Classification BE2Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Prostaglandin E synthase (PTGES) DTT PTGES 7.92E-02 -0.05 -0.24
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004.
2 Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059.