Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM89PMC)

Drug Name

VUF-10148 Drug Info

Synonyms

VUF-10148; CHEMBL261551; 1001065-53-7; VUF 10148; 3-Benzyl-2-(4-methylpiperazinyl)-quinoxaline; SCHEMBL602972; MolPort-027-564-855; PQQUQVYOCGJWAX-UHFFFAOYSA-N; KS-00002WX1; ZINC29054164; BDBM50412496; AKOS016340709; MG-0235

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 24759623
TTD Drug ID: DM89PMC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Inhibitor	[1]
Histamine H2 receptor (H2R)	TTQHJ1K	HRH2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Histamine H1 receptor (H1R)	DTT	HRH1	5.972	5.7	5.816	6.002
Histamine H2 receptor (H2R)	DTT	HRH2	5.087	5.121	4.661	4.609

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H1 receptor (H1R)	DTT	HRH1	6.74E-01	0.13	0.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo. J Med Chem. 2008 Apr 24;51(8):2457-67.