Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8LRU2)

Drug Name

Revolade/Promacta Drug Info

Synonyms

AC1OC7GM

Indication

Disease Entry	ICD 11	Status	REF
Idiopathic thrombocytopenic purpura	3B64.10	Approved	[1]
Chronic liver disease	DB99.0	Phase 3	[1]
Thrombocytopenia	3B64	Phase 2	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thrombopoietin receptor (MPL)	TTIHYA4	TPOR_HUMAN	Agonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Thrombopoietin receptor (MPL)	DTT	MPL	2.7	3.186	2.35	3.766

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Idiopathic thrombocytopenic purpura

ICD Disease Classification

3B64.10

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Thrombopoietin receptor (MPL)	DTT	MPL	2.61E-06	0.1	0.45

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022291.
2	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).