Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM920XR)

Drug Name

8-(3,5-dimethoxyphenyl)-9H-purine-2,6-diamine Drug Info

Synonyms

8-(3,5-dimethoxyphenyl)-9H-purine-2,6-diamine; CHEMBL105323; AC1LAR96; CTK6J9242; BDBM50059940; 2,6-Diamino-8-(3',5'-dimethoxyphenyl)purine; 8-(3,5-dimethoxyphenyl)-7H-purine-2,6-diamine; 8-(3,5-dimethoxyphenyl)-3h-purine-2,6-diamine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 473571
TTD Drug ID: DM920XR

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Polypeptide deformylase (PDF)	TT9SL3Q	DEFM_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Polypeptide deformylase (PDF)	DTT	PDF	8.87E-16	-0.54	-0.86

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701.