Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM98L2X)

Drug Name

(R)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline Drug Info

Synonyms

(R)-3-Methyl-1,2,3,4-tetrahydroisoquinoline; 179893-97-1; CHEMBL293023; (3R)-3-methyl-1,2,3,4-tetrahydroisoquinoline; AC1OM1IT; (R)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline; SCHEMBL1690519; Isoquinoline, 1,2,3,4-tetrahydro-3-methyl-, (3R)-; UEKQPSAKUNXFHL-MRVPVSSYSA-N; ZINC19928405; FCH952510; BDBM50052885; AKOS024259472; AJ-75700

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 7462300
TTD Drug ID: DM98L2X

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2A (ADRA2A)	TTWG9A4	ADA2A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2B (ADRA2B)	TTWM4TY	ADA2B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	5.013	2.379	5.594	2.07

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	1.76E-01	-0.06	-0.28

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46.