Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9B68S)

Drug Name
POL-6014 Drug Info
Synonyms Serine protease inhibitors (inhaled, PEM, asthma/COPD), Polyphor
Indication
Disease Entry ICD 11 Status REF
Cystic fibrosis CA25 Phase 1 [1]
Chronic obstructive pulmonary disease CA22 Investigative [2]
Cross-matching ID
PubChem CID
71532754
TTD Drug ID
DM9B68S

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Neutrophil elastase (NE) TTPLTSQ ELNE_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Neutrophil elastase (NE) DTT ELANE 2.379 2.036 1.379 2.945
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Cystic fibrosis
ICD Disease Classification CA25
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Neutrophil elastase (NE) DTT ELANE 7.82E-01 0.09 0.3
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Anti-ageing pipeline starts to mature.Nat Rev Drug Discov. 2018 Sep;17(9):609-612.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2358).