Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9IPTV)

• Drug Name: N-Hydroxy-3-phenyl-acrylamide Drug Info
• Synonyms: Cinnamoylhydroxamic acid; CINNAMOHYDROXAMIC ACID; Hydroxylamine, N-cinnamoyl-; 2-Propenamide, N-hydroxy-3-phenyl-; N-Hydroxycinnamamide; UNII-434STJ4H11; N-Hydroxy-3-phenyl-2-propenamide; NSC 42128; NSC-42128; NSC-44617; NSC 44617; CHEMBL154574; 3669-32-7; 434STJ4H11; WLN: QMV1U1R; N-Hydroxy-3-phenyl-acrylamide; Cinnamohydroxamic acid, (E)-; Cinnamoylhydroxamic acid [INCI]; MAZ 1704; MAZ-1704; 2-Propenamide, N-hydroxy-3-phenyl-, (E)-; 2-Propenamide, N-hydroxy-3-phenyl-, (2E)-; AC1Q5CS7; AC1NS7U4; SCHEMBL559917

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5355635
  CAS Number: CAS 3669-32-7
  TTD Drug ID: DM9IPTV

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

References

• [1] Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8.