Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9QUCH)

Drug Name

ASP0598 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Chronic tympanic membrane perforation	AB13	Phase 1	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Proheparin-binding EGF-like growth factor (HBEGF)	TT15SL0	HBEGF_HUMAN	Replacement	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Proheparin-binding EGF-like growth factor (HBEGF)	DTT	HBEGF	4.07	4.248	3.644	5.044

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Chronic tympanic membrane perforation

ICD Disease Classification

AB13

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Proheparin-binding EGF-like growth factor (HBEGF)	DTT	HBEGF	3.92E-01	0.06	0.12

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT04305184) A Phase 1/2, Randomized, Placebo-controlled Study to Assess the Safety, Tolerability, Efficacy, and Pharmacokinetics of ASP0598 Otic Solution Following Topical Application Into the Ear in Subjects With Chronic Tympanic Membrane Perforation (CTMP). U.S.National Institutes of Health.