Details of the Drug

General Information of Drug (ID: DM9QUCH)

Drug Name

ASP0598

Indication

Disease Entry	ICD 11	Status	REF
Chronic tympanic membrane perforation	AB13	Phase 1	[1]
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Drug Type

Recombinant protein

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Proheparin-binding EGF-like growth factor (HBEGF)	TT15SL0	HBEGF_HUMAN	Replacement	[1]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Chronic tympanic membrane perforation

ICD Disease Classification

AB13

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Proheparin-binding EGF-like growth factor (HBEGF)	DTT	HBEGF	3.92E-01	0.06	0.12

Molecular Expression Atlas (MEA)

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References

1	ClinicalTrials.gov (NCT04305184) A Phase 1/2, Randomized, Placebo-controlled Study to Assess the Safety, Tolerability, Efficacy, and Pharmacokinetics of ASP0598 Otic Solution Following Topical Application Into the Ear in Subjects With Chronic Tympanic Membrane Perforation (CTMP). U.S.National Institutes of Health.