General Information of Drug (ID: DM9S5V0)

Drug Name
4'-Amino-4-hydroxychalcone Drug Info
Synonyms
CHEMBL383563; 1-(4-aminophenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one; 4''-Amino-4-hydroxychalcone; AC1O21K2; SCHEMBL3762443; MolPort-019-723-769; ZINC4099897; SBB099103; BDBM50174839; AN-308/25123008; (2E)-1-(4-aminophenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4525387
TTD Drug ID
DM9S5V0

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tyrosinase (TYR) TTULVH8 TYRO_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Tyrosinase (TYR) DTT TYR 5.959 5.711 5.973 4.912
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tyrosinase (TYR) DTT TYR 6.68E-04 2.54 1.15
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone. Eur J Med Chem. 2010 May;45(5):2010-7.