Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9SLUK)

Drug Name

PMID22595175C4g Drug Info

Synonyms

GTPL8626; BDBM50384111

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cathepsin G (CTSG)	TTQAJF1	CATG_HUMAN	Inhibitor	[1]
Leukocyte proteinase-3 (PRTN3)	TT5MLC4	PRTN3_HUMAN	Inhibitor	[1]
Neutrophil elastase (NE)	TTPLTSQ	ELNE_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Cathepsin G (CTSG)	DTT	CTSG	4.293	5.031	4.65	4.781
Neutrophil elastase (NE)	DTT	ELANE	2.379	2.036	1.379	2.945
Leukocyte proteinase-3 (PRTN3)	DTT	PRTN3	5.558	2.828	4.138	5.236

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cathepsin G (CTSG)	DTT	CTSG	1.80E-01	-0.43	-1.03
Neutrophil elastase (NE)	DTT	ELANE	2.35E-01	-0.55	-0.82

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3993-7.