Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9UZD7)

Drug Name
Bile acid Drug Info
Synonyms Bile Salts; Bile acid; Bile salt; CHEBI:22868
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
439520
ChEBI ID
CHEBI:22868
TTD Drug ID
DM9UZD7
INTEDE Drug ID
DR2509

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
G-protein coupled bile acid receptor 1 (GPBAR1) TTSDVTR GPBAR_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Cytochrome P450 7A1 (CYP7A1) DEDZRQ1 CP7A1_HUMAN Phase 1 [2]

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
G-protein coupled bile acid receptor 1 (GPBAR1) DTT GPBAR1 4.60E-01 0.02 0.09
Cytochrome P450 7A1 (CYP7A1) DME CYP7A1 9.79E-01 -7.86E-01 -3.93E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5718-21.
2 FGF15 activates Hippo signaling to suppress bile acid metabolism and liver tumorigenesis. Dev Cell. 2019 Feb 25;48(4):460-474.e9.