Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMA25NO)

Drug Name

MK-4214 Drug Info

Synonyms

INS-19; Recombinant human GCSF (biosimilar), Insmed

Indication

Disease Entry	ICD 11	Status	REF
Neutropenia	4B00.0	Phase 3	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Granulocyte colony-stimulating factor (CSF3)	TT5TQ2W	CSF3_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Granulocyte colony-stimulating factor (CSF3)	DTT	CSF3	1.963	2.07	3.446	2.485

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Neutropenia

ICD Disease Classification

4B00.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Granulocyte colony-stimulating factor (CSF3)	DTT	CSF3	7.72E-01	-1.68E-03	-0.01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Clinical pipeline report, company report or official report of Merck.
2	DOI: 10.1038/nbt0710-636a