Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMA85ND)

Drug Name
ET-1 Drug Info
Synonyms Endothelin-1
Cross-matching ID
PubChem CID
16212950
CAS Number
CAS 123626-67-5
TTD Drug ID
DMA85ND
INTEDE Drug ID
DR1936

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Endothelin A receptor (EDNRA) TTKRD0G EDNRA_HUMAN Inhibitor [1]
Endothelin B receptor (EDNRB) TT3ZTGU EDNRB_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Carboxypeptidase A4 (CPA4) DEXKD7J CBPA4_HUMAN Preclinical [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Endothelin A receptor (EDNRA) DTT EDNRA 3.776 4.505 5.121 3.536
Carboxypeptidase A4 (CPA4) DME CPA4 6.154 6.517 6.736 6.555
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Endothelin A receptor (EDNRA) DTT EDNRA 3.19E-05 -2.69 -1.71
Carboxypeptidase A4 (CPA4) DME CPA4 9.64E-06 -1.66E+00 -1.83E+00
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 5-OHKF and NorKA, depsipeptides from a Hawaiian collection of Bryopsis pennata: binding properties for NorKA to the human neuropeptide Y Y1 receptor. J Nat Prod. 2009 Dec;72(12):2172-6.
2 IRL 2500: A potent ETB selective endothelin antagonist, Bioorg. Med. Chem. Lett. 6(19):2323-2328 (1996).
3 Rapid degradation of endothelin-1 by an enzyme released by the rat isolated perfused mesentery. Br J Pharmacol. 1995 Feb;114(4):867-71.