Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAB9QE)

Drug Name
Nivolumab Drug Info
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Approved [1]
Non-small-cell lung cancer 2C25.Y Approved [2]
Esophageal cancer 2B70 Phase 3 [3]
Gastric adenocarcinoma 2B72 Phase 3 [3]
Malignant pleural mesothelioma 2C26.0 Phase 3 [3]
Multiple myeloma 2A83 Phase 3 [3]
Recurrent glioblastoma 2A00.00 Phase 3 [3]
Small-cell lung cancer 2C25.Y Phase 3 [3]
Central nervous system lymphoma 2B33.5 Phase 2 [3]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [4]
Diffuse large B-cell lymphoma 2A81 Phase 2 [3]
Follicular lymphoma 2A80 Phase 2 [3]
Prostate cancer 2C82.0 Phase 2 [3]
Ovarian cancer 2C73 Phase 1/2 [3]
Pancreatic cancer 2C10 Phase 1/2 [3]
Triple negative breast cancer 2C60-2C65 Phase 1/2 [3]
Chronic myelogenous leukaemia 2A20.0 Phase 1 [3]
Renal cell carcinoma 2C90 Application submitted [3]
Lung squamous cell carcinoma 2C25.2 Investigative [5]
Cross-matching ID
TTD Drug ID
DMAB9QE

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Programmed cell death protein 1 (PD-1) TTNBFWK PDCD1_HUMAN Modulator [6]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Programmed cell death protein 1 (PD-1) DTT PDCD1 5.635 4.661 4.706 5.15
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Skin
The Studied Disease Melanoma [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Programmed cell death protein 1 (PD-1) DTT PDCD1 7.26E-01 -0.01 -0.03
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7335).
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 COVID-19: A Pilot Study of Adaptive Immunity and Anti-PD1
5 The Current Landscape of Immune Checkpoint Blockade in Metastatic Lung Squamous Cell Carcinoma. Molecules. 2021 Mar 5;26(5):1392.
6 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.