Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAF43E)

Drug Name

(3,4-dimethylphenyl)(4-phenoxyphenyl)methanone Drug Info

Synonyms

(3,4-dimethylphenyl)(4-phenoxyphenyl)methanone; CHEMBL557722; CBDivE_001397; AC1MOFBF; AC1Q2DSA; Oprea1_371703; Oprea1_274103; MolPort-001-813-132; (3,4-DIMETHYL-PHENYL)-(4-PHENOXY-PHENYL)-METHANONE; ZINC2496519; STK333119; BDBM50296685; AKOS024330770; MCULE-5159255282

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3342765
TTD Drug ID: DMAF43E

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 1 (mGluR1)	TTVBPDM	GRM1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Metabotropic glutamate receptor 1 (mGluR1)	DTT	GRM1	3.888	3.848	3.711	3.678

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Metabotropic glutamate receptor 1 (mGluR1)	DTT	GRM1	2.31E-01	-0.05	-0.2
Metabotropic glutamate receptor 1 (mGluR1)	DTT	GRM1	2.46E-02	0.11	0.74

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate recepto... Bioorg Med Chem. 2009 Aug 1;17(15):5708-15.