Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAGFOD)

Drug Name
Semaglutide Drug Info
Synonyms NN9535
Indication
Disease Entry ICD 11 Status REF
Type-2 diabetes 5A11 Approved [1]
Cross-matching ID
PubChem CID
56843331
CAS Number
CAS 910463-68-2
TTD Drug ID
DMAGFOD
INTEDE Drug ID
DR1473
ACDINA Drug ID
D01423

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glucagon-like peptide 1 receptor (GLP1R) TTVIMDE GLP1R_HUMAN Agonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Neprilysin (MME) DEVN830 NEP_HUMAN Approved [3]
Dipeptidyl peptidase IV (DPP4) DEKZQY6 DPP4_HUMAN Approved [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Glucagon-like peptide 1 receptor (GLP1R) DTT GLP1R 2 2.848 3.472 2.963
Neprilysin (MME) DME MME 4.902 3.07 6.988 9.452
Dipeptidyl peptidase IV (DPP4) DME DPP4 4.995 4.926 7.852 8.358
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Type-2 diabetes
ICD Disease Classification 5A11
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glucagon-like peptide 1 receptor (GLP1R) DTT GLP1R 1.25E-01 0.17 1.26
Neprilysin (MME) DME MME 3.54E-01 4.98E-01 9.92E-01
Dipeptidyl peptidase IV (DPP4) DME DPP4 9.54E-01 -2.74E-01 -1.85E+00
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249).
3 Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species. Eur J Pharm Sci. 2017 Jun 15;104:31-41.