Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAK3V7)

Drug Name

DIO-901 Drug Info

Synonyms

CAM-4044; VLD glucagon (diabetes), DiObex; Very low dose glucagon (diabetes), DiObex; VLD glucagon (FluidCrystal, diabetes), DiObex; VLD glucagon (extended-release, diabetes) DiObex

Indication

Disease Entry	ICD 11	Status	REF
Type-1 diabetes	5A10	Terminated	[1]

Cross-matching ID

TTD Drug ID: DMAK3V7

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucagon receptor (GCGR)	TT9O6WS	GLR_HUMAN	Agonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glucagon receptor (GCGR)	DTT	GCGR	4.695	1.926	1.322	3.797

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Type-1 diabetes

ICD Disease Classification

5A10

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glucagon receptor (GCGR)	DTT	GCGR	7.24E-02	-0.52	-0.92

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022421)
2	Effects of low-dose and high-dose glucagon on glucose production and gluconeogenesis in humans. Metabolism. 2000 Jan;49(1):39-46.