Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAM3OH)

Drug Name

SUN-E3001 Drug Info

Synonyms

CHS-13340; PTH[1,34], Suntory; RhPTH(1-34); RhPTH[1,34], Daiichi Asubio Pharma; Recombinant human parathyroid hormone[residues 1-34] (osteoporosis), Asubio Pharma; RhPTH[1,34] (osteporosis), Asubio Pharma

Indication

Disease Entry	ICD 11	Status	REF
Osteoporosis	FB83.0	Terminated	[1]

Cross-matching ID

TTD Drug ID: DMAM3OH

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Parathyroid hormone (PTH)	TT6F7GZ	PTHY_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Parathyroid hormone (PTH)	DTT	PTH	-0.737	1.485	1.322	0

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification

15 Disease of the musculoskeletal system/connective tissue

Disease Class

ICD-11: FA20 Rheumatoid arthritis

The Studied Tissue

Bone marrow

The Studied Disease

Osteoporosis [ICD-11:FA20]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Parathyroid hormone (PTH)	DTT	PTH	3.70E-01	0.08	0.66

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014905)
2	Effects of teriparatide [recombinant human parathyroid hormone (1-34)] on cortical bone in postmenopausal women with osteoporosis. J Bone Miner Res. 2003 Mar;18(3):539-43.