Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAMJW2)

Drug Name

8-Acetyl-7-hydroxy-2H-chromen-2-one Drug Info

Synonyms

8-Acetyl-7-hydroxycoumarin; 6748-68-1; 8-acetyl-7-hydroxy-2H-chromen-2-one; 7-hydroxy-8-acetylcoumarin; CHEMBL446518; AN-829/13872055; AC1NTTTW; SCHEMBL4639845; CTK5C6237; 8-acetyl-7-hydroxychromen-2-one; DTXSID40419935; MolPort-003-821-703; 8-acetyl-7-hydroxy-2-oxochromene; ZINC366861; 8-acetyl-7-hydroxy-chromen-2-one; 8-Acetyl-7-hydroxycoumarin, 97%; BDBM50332038; MFCD00270162; 8 - Acetyl - 7 - hydroxycoumarin; AKOS022647720; OR345001; KB-200256; ST50309088; Z3067; 2H-1-Benzopyran-2-one, 8-acetyl-7-hydroxy-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5411574
CAS Number: CAS 6748-68-1
TTD Drug ID: DMAMJW2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase IX (CA-IX)	DTT	CA9	6.08E-15	2.8	7.25

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8.