Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAY4OZ)

Drug Name

3-Nitro-benzenesulfonamide Drug Info

Synonyms

3-Nitrobenzenesulfonamide; 121-52-8; Benzenesulfonamide, 3-nitro-; m-Nitrobenzenesulfonamide; 3-Nitrobenzolesulfamide; m-Nitrobenzenesulphonamide; 3-nitrobenzenesulphonamide; 3-Nitro-benzenesulfonamide; Benzenesulfonamide, m-nitro-; 3-nitrobenzene-1-sulfonamide; CHEMBL367035; TXTQURPQLVHJRE-UHFFFAOYSA-N; EINECS 204-477-8; NSC 407487; m-nitrobenzolsulfonamid; 3-nitrophenylsulfonamide; AI3-50018; AC1Q1GYY; 3-nitro-benzenesulfonamid; m-Nitrobenzene sulfonamide; 3-nitrophenyl sulphonamide; 3-nitrobenzene sulfonamide; AC1L26XH

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 67138
CAS Number: CAS 121-52-8
TTD Drug ID: DMAY4OZ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7.