Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMB7EIN)

Drug Name

PF-915275 Drug Info

Synonyms

PF-915275; 857290-04-1; PF 915275; UNII-388927163B; N-(6-aminopyridin-2-yl)-4'-cyanobiphenyl-4-sulfonamide; 388927163B; ZESFDAKNYJQYKO-UHFFFAOYSA-N; SCHEMBL4384483; CHEMBL495841; CTK5F5674; BDBM29864; DTXSID00235037; MolPort-023-276-737; KS-00001D9U; BCP28049; ZINC40955326; AKOS024457530; CS-5559; N-(Pyridin-2-yl) arylsulfonamide, 26; NCGC00370811-01; HY-18056; RT-015014; KB-274983; B7346; N-(6-Aminopyridin-2-yl)4'-cyanobiphenyl-4-sulfonamide; N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide

Indication

Disease Entry	ICD 11	Status	REF
Non-insulin dependent diabetes	5A11	Discontinued in Phase 1	[1]

Cross-matching ID

PubChem CID: 23725123
CAS Number: CAS 857290-04-1
TTD Drug ID: DMB7EIN

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	TTN7BL9	DHI1_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	10.967	5.178	5.865	6.377

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Non-insulin dependent diabetes

ICD Disease Classification

5A11

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	2.03E-01	-0.01	-0.08

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025590)
2	N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3493-7.