Details of the Drug

General Information of Drug (ID: DMB7EIN)

Drug Name

PF-915275

Synonyms

PF-915275; 857290-04-1; PF 915275; UNII-388927163B; N-(6-aminopyridin-2-yl)-4'-cyanobiphenyl-4-sulfonamide; 388927163B; ZESFDAKNYJQYKO-UHFFFAOYSA-N; SCHEMBL4384483; CHEMBL495841; CTK5F5674; BDBM29864; DTXSID00235037; MolPort-023-276-737; KS-00001D9U; BCP28049; ZINC40955326; AKOS024457530; CS-5559; N-(Pyridin-2-yl) arylsulfonamide, 26; NCGC00370811-01; HY-18056; RT-015014; KB-274983; B7346; N-(6-Aminopyridin-2-yl)4'-cyanobiphenyl-4-sulfonamide; N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide

Indication

Disease Entry	ICD 11	Status	REF
Non-insulin dependent diabetes	5A11	Discontinued in Phase 1	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

350.4

Logarithm of the Partition Coefficient (xlogp)

2.7

Rotatable Bond Count (rotbonds)

4

Hydrogen Bond Donor Count (hbonddonor)

2

Hydrogen Bond Acceptor Count (hbondacc)

6

Chemical Identifiers

Formula: C18H14N4O2S
IUPAC Name: N-(6-aminopyridin-2-yl)-4-(4-cyanophenyl)benzenesulfonamide
Canonical SMILES: C1=CC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N
InChI: InChI=1S/C18H14N4O2S/c19-12-13-4-6-14(7-5-13)15-8-10-16(11-9-15)25(23,24)22-18-3-1-2-17(20)21-18/h1-11H,(H3,20,21,22)
InChIKey: ZESFDAKNYJQYKO-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 23725123
CAS Number: 857290-04-1
TTD ID: D07FHW

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	TTN7BL9	DHI1_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Gene/Protein Processing	[3]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Non-insulin dependent diabetes

ICD Disease Classification

5A11

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	2.03E-01	-0.01	-0.08

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025590)
2	N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3493-7.
3	Induction of 11-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells. Mol Endocrinol. 2013 Feb;27(2):192-202. doi: 10.1210/me.2012-1247. Epub 2012 Dec 28.