Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMB9587)

Drug Name
Amocarzine Drug Info
Synonyms Phenthiourezine; Thiocarbamazine; CGP-6140; S-80016
Indication
Disease Entry ICD 11 Status REF
Helminth infection 1F90.0 Phase 3 [1]
Cross-matching ID
PubChem CID
5464102
ChEBI ID
CHEBI:38946
CAS Number
CAS 36590-19-9
TTD Drug ID
DMB9587

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetylcholinesterase (AChE) TT1RS9F ACES_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Acetylcholinesterase (AChE) DTT ACHE 1.678 1.926 1.766 5.252
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Helminth infection
ICD Disease Classification 1F90.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Acetylcholinesterase (AChE) DTT ACHE 6.39E-02 -1.07 -1.15
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 The safety and efficacy of amocarzine in African onchocerciasis and the influence of ivermectin on the clinical and parasitological response to treatment. Ann Trop Med Parasitol. 1997 Apr;91(3):281-96.
2 Activity, mechanism of action and pharmacokinetics of 2-tert-butylbenzothiazole and CGP 6140 (amocarzine) antifilarial drugs. Acta Trop. 1992 Aug;51(3-4):195-211.