Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT1RS9F)

DTT Name	Acetylcholinesterase (AChE)
Synonyms	YT; N-ACHE; ARACHE
Gene Name	ACHE
DTT Type	Successful target	[1]
BioChemical Class	Carboxylic ester hydrolase
UniProt ID	ACES_HUMAN
TTD ID	T30082
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC 3.1.1.7
Sequence	MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN QFDHYSKQDRCSDL
Function	Role in neuronal apoptosis. Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
KEGG Pathway	Glycerophospholipid metabolism (hsa00564 ) Cholinergic synapse (hsa04725 )
Reactome Pathway	Synthesis of PC (R-HSA-1483191 ) Synthesis, secretion, and deacylation of Ghrelin (R-HSA-422085 ) Neurotransmitter clearance (R-HSA-112311 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DTT

15 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ambenonium	DMOP0BL	Myasthenia gravis	8C6Y	Approved	[2]
Demecarium bromide	DMAYEU1	Open-angle glaucoma	9C61	Approved	[3]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[1]
Echothiophate Iodide	DMSNVGB	Chronic glaucoma	9C61.0Z	Approved	[4]
Edrophonium	DMCRQHB	Myasthenia gravis	8C6Y	Approved	[5]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[6]
Huperzine A	DMMAWLU	Alzheimer disease	8A20	Approved	[7]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[8]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[9]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[5]
Pralidoxime Chloride	DMGQ0ZI	Poisoning due to pesticides and chemicals	NE6Z	Approved	[4]
Pyridostigmine	DM8HO1L	Myasthenia gravis	8C6Y	Approved	[10]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[1]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[11]
YM443	DMNZCI1	Functional dyspepsia	DD90.3	Approved	[12]
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⏷ Show the Full List of 15 Approved Drug(s)

17 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(-)-Phenserine	DMNCY1I	Alzheimer disease	8A20	Phase 3	[13]
Amocarzine	DMB9587	Helminth infection	1F90.0	Phase 3	[14]
Eptastigmine	DMTV7ZM	Cognitive impairment	6D71	Phase 3	[15]
INM-176	DMLG96Z	Alzheimer disease	8A20	Phase 3	[16]
Suronacrine maleate	DMH2FN1	Cognitive impairment	6D71	Phase 3	[17]
AD-35	DMVDQO6	Alzheimer disease	8A20	Phase 2	[18]
Ladostigil	DMJSY3Q	Alzheimer disease	8A20	Phase 2	[19]
Methanesulfonyl fluoride	DMS7FRI	Alzheimer disease	8A20	Phase 2	[20]
R-phenserine	DM4L5VJ	Alzheimer disease	8A20	Phase 2	[21]
T-82	DM4JFMZ	Cognitive impairment	6D71	Phase 2	[22]
CPC-212	DM3J1T9	Alzheimer disease	8A20	Phase 1	[23]
CPC-250	DMDQG4Y	Alzheimer disease	8A20	Phase 1	[23]
Desoxypeganine	DMTR7EH	Alcohol dependence	6C40.2	Phase 1	[24]
GTP-004	DM20HS7	Myasthenia gravis	8C6Y	Phase 1	[23]
KW-5092	DMALK7F	Pain	MG30-MG3Z	Phase 1	[25]
PRX-105	DMWT8RI	Poison intoxication	NE6Z	Phase 1	[26]
ZT-1	DMO2WYX	Parkinson disease	8A00.0	Phase 1	[27]
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⏷ Show the Full List of 17 Clinical Trial Drug(s)

54 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-PAM derivative 1	DMI4KBC	N. A.	N. A.	Patented	[28]
4-PAM derivative 1	DMN37BI	N. A.	N. A.	Patented	[28]
Amidine oxime derivative 1	DM8STUQ	N. A.	N. A.	Patented	[28]
Decyle nelycorine dibromo salt derivative 1	DMXKUMJ	N. A.	N. A.	Patented	[29]
Di-substituted piperidine derivative 2	DM23XQL	N. A.	N. A.	Patented	[29]
Egonol compound 1	DMQF1UM	N. A.	N. A.	Patented	[28]
Fluorinated donepezil derivative 1	DMQOGHN	N. A.	N. A.	Patented	[28]
Fluorinated donepezil derivative 2	DMV1SCA	N. A.	N. A.	Patented	[28]
Galantamine analog 1	DM5BVCS	N. A.	N. A.	Patented	[28]
Indoline derivative 1	DMJ41UI	N. A.	N. A.	Patented	[29]
Isochroman-4-ketone derivative 1	DMDBK6O	N. A.	N. A.	Patented	[29]
Lycorine dimer salt derivative 1	DMGKQXP	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-12	DMBNHI7	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-13	DMY5UB8	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-14	DMGI5Z8	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-15	DMEW46T	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-27	DMO0QME	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-28	DMVM31E	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-3	DM7JIF0	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-36	DM7CWZ4	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-39	DMQOAJP	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-42	DM68KPS	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-43	DM12X0P	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-47	DMEXATH	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-48	DM81A50	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-49	DMQTRFX	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-51	DMNH891	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-52	DMRH7ZY	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-7	DMAN71J	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-neostenine	DM7TLDW	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-neotuberostemonine	DM3CPJQ	N. A.	N. A.	Patented	[28]
PMID27967267-Compound-stenine	DM2K54D	N. A.	N. A.	Patented	[28]
PMID29757691-Compound-10	DMZBHR9	N. A.	N. A.	Patented	[29]
PMID29757691-Compound-2a	DMEUC04	N. A.	N. A.	Patented	[29]
PMID29757691-Compound-2a-i	DMBRQP1	N. A.	N. A.	Patented	[29]
PMID29757691-Compound-4	DMFD9UZ	N. A.	N. A.	Patented	[29]
PMID29757691-Compound-7	DM7TPBF	N. A.	N. A.	Patented	[29]
PMID29757691-Compound-8a	DM5IFBV	N. A.	N. A.	Patented	[29]
PMID29757691-Compound-8b	DMEOZKF	N. A.	N. A.	Patented	[29]
PMID29757691-Compound-8c	DMHL7SW	N. A.	N. A.	Patented	[29]
PMID29757691-Compound-8d	DM6PDEH	N. A.	N. A.	Patented	[29]
Quinazoline alkaloid derivative 1	DMH86F2	N. A.	N. A.	Patented	[29]
Tacrine heterodimer derivative 1	DMFOKRW	N. A.	N. A.	Patented	[29]
Tacrine-caffeic acid hybrid derivative 1	DMJ04RQ	N. A.	N. A.	Patented	[28]
Tacrine-caffeic acid hybrid derivative 2	DMMVPSY	N. A.	N. A.	Patented	[28]
Tacrine-dihydropyridine hybrid derivative 1	DMK0S4I	N. A.	N. A.	Patented	[28]
Tacrine-indole hybrid derivative 1	DMQ3K5B	N. A.	N. A.	Patented	[28]
Tacrine-indole hybrid derivative 2	DMH9N2T	N. A.	N. A.	Patented	[28]
Tacrine-indole hybrid derivative 3	DMUTKNW	N. A.	N. A.	Patented	[28]
Tacrine-phenothiazine hybrid derivative 1	DMNGY8R	N. A.	N. A.	Patented	[28]
Tetra-hydro-isoquinoline derivative 1	DML86IO	N. A.	N. A.	Patented	[29]
Tetra-hydro-isoquinoline derivative 2	DM5CKVF	N. A.	N. A.	Patented	[29]
Tetra-hydro-isoquinoline derivative 3	DMCZA45	N. A.	N. A.	Patented	[29]
Tetra-hydro-isoquinoline derivative 4	DMDV0MP	N. A.	N. A.	Patented	[29]
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⏷ Show the Full List of 54 Patented Agent(s)

20 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VELNACRINE	DMUB0EC	Cognitive impairment	6D71	Discontinued in Phase 3	[30]
Zanapezil	DMTCP8H	Alzheimer disease	8A20	Discontinued in Phase 3	[31]
Caracemide	DMNOLHT	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[32]
HP-290	DMUMGCY	Parkinson disease	8A00.0	Discontinued in Phase 2	[33]
Icopezil maleate	DM5WUK9	Cognitive impairment	6D71	Discontinued in Phase 2	[34]
Physostigmine	DM2N0TO	Xerostomia	DA02.1	Discontinued in Phase 2	[35]
S-9977	DMEO6A5	Cognitive impairment	6D71	Discontinued in Phase 2	[36]
SM-10888	DMBUH7E	Cognitive impairment	6D71	Discontinued in Phase 2	[37]
TAK-802	DMHNZ31	Urinary dysfunction	GC2Z	Discontinued in Phase 2	[38]
ZIFROSILONE	DMC6H4Y	Cognitive impairment	6D71	Discontinued in Phase 2	[39]
NP-61	DMXI5YW	Alzheimer disease	8A20	Discontinued in Phase 1	[40]
7-methoxytacrine	DMX5K4C	N. A.	N. A.	Terminated	[42]
ABS-301	DMCW5DJ	Alzheimer disease	8A20	Terminated	[43]
CI-1002	DMJ2P1Q	Alzheimer disease	8A20	Terminated	[44]
F-3796	DMXB8SE	Alzheimer disease	8A20	Terminated	[45]
FR-152558	DMOEYX2	Alzheimer disease	8A20	Terminated	[46]
MF-8615	DM47WS2	Alzheimer disease	8A20	Terminated	[47]
MF268	DMHV5OD	Alzheimer disease	8A20	Terminated	[48]
NP-7557	DM4B1VF	Alzheimer disease	8A20	Terminated	[49]
Ro-46-5934	DMU9JAH	Alzheimer disease	8A20	Terminated	[50]
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⏷ Show the Full List of 20 Discontinued Drug(s)

2 Preclinical Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PHENSERINE TARTRATE	DMIGH6W	Parkinson disease	8A00.0	Preclinical	[21]
SPH-1285	DMMA2ZW	Alzheimer disease	8A20	Preclinical	[41]
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220 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(-)-huperzine B	DMBO9J3	Discovery agent	N.A.	Investigative	[51]
(-)-Tolserine	DMAT58Z	Discovery agent	N.A.	Investigative	[13]
(1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATE	DMCVKTB	Discovery agent	N.A.	Investigative	[48]
(2-Butyryloxy-ethyl)-trimethyl-ammonium iodide	DMLTMPC	Discovery agent	N.A.	Investigative	[52]
(2-Chloro-ethyl)-trimethyl-ammonium chloride	DM6DH15	Discovery agent	N.A.	Investigative	[52]
(2-Ethoxy-ethyl)-trimethyl-ammonium iodide	DMN7XT9	Discovery agent	N.A.	Investigative	[52]
(2-Mercapto-ethyl)-trimethyl-ammonium iodide	DMCJKOQ	Discovery agent	N.A.	Investigative	[52]
(24S)-ethylcholesta-7,9(11),22(E)-triene-3b-ol	DMPL80G	Discovery agent	N.A.	Investigative	[53]
(3-Bromo-propyl)-trimethyl-ammonium	DMUJ18K	Discovery agent	N.A.	Investigative	[52]
(3-Hydroxy-2-methyl-phenyl)-trimethyl-ammonium	DM08UQF	Discovery agent	N.A.	Investigative	[52]
(3R)-9-amino-3-methyl-1,2,3,4-tetrahydroacridine	DMEUBGY	Discovery agent	N.A.	Investigative	[54]
(4-Bromo-butyl)-trimethyl-ammonium	DMU1HFM	Discovery agent	N.A.	Investigative	[52]
(4-Iodo-butyl)-trimethyl-ammonium iodide	DMOWFE5	Discovery agent	N.A.	Investigative	[52]
(5-Bromo-pentyl)-trimethyl-ammonium	DM4EH2J	Discovery agent	N.A.	Investigative	[52]
(R)-tacrine(10)-hupyridone	DMSFA2D	Discovery agent	N.A.	Investigative	[48]
(RS)-tacrine(10)-hupyridone	DMCN6WR	Discovery agent	N.A.	Investigative	[51]
(S)-tacrine(10)-hupyridone	DMH7QZ2	Discovery agent	N.A.	Investigative	[48]
(S,S)-(-)-bis(10)-hupyridone	DMBR1JS	Discovery agent	N.A.	Investigative	[51]
(S,S)-(-)-bis(12)-hupyridone	DM6PQ8D	Discovery agent	N.A.	Investigative	[51]
1,10-bis(pyridinium)-decane dibromide	DM6VCI3	Discovery agent	N.A.	Investigative	[55]
1,11-bis(pyridinium)-undecane dibromide	DMVXYZL	Discovery agent	N.A.	Investigative	[55]
1,2-Di(berberine-9-O-yl)ethane dibromide	DM7S1D5	Discovery agent	N.A.	Investigative	[56]
1,2-NAPHTHOQUINONE	DMYXELH	Discovery agent	N.A.	Investigative	[57]
1,3-Bis-(3-imidazolidin-2-yl-phenyl)-urea	DM78UPQ	Discovery agent	N.A.	Investigative	[58]
1,3-Di(berberine-9-O-yl)ethane dibromide	DMZKUOX	Discovery agent	N.A.	Investigative	[56]
1,4-Di(berberine-9-O-yl)ethane dibromide	DM87MWN	Discovery agent	N.A.	Investigative	[56]
1,9-bis(pyridinium)-nonane dibromide	DMWC7QE	Discovery agent	N.A.	Investigative	[55]
1-(3-Bromomethyl-phenyl)-2,2,2-trifluoro-ethanone	DM58S47	Discovery agent	N.A.	Investigative	[59]
1-benzene sulfonyl-cis-2,6-dimethyl piperidine	DMQ1EVT	Discovery agent	N.A.	Investigative	[60]
1-Deoxy-1-Thio-Heptaethylene Glycol	DMAEWHB	Discovery agent	N.A.	Investigative	[48]
1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE	DMJBFN0	Discovery agent	N.A.	Investigative	[48]
10-Hydroxy-infractopicrin	DM5H73W	Discovery agent	N.A.	Investigative	[61]
2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine	DMYHFUO	Discovery agent	N.A.	Investigative	[62]
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose	DMOUG6Y	Discovery agent	N.A.	Investigative	[63]
2-(N-Morpholino)-Ethanesulfonic Acid	DMZVHSB	Discovery agent	N.A.	Investigative	[63]
2-Hex-5-enyl-5-non-8-enyl-3,4-dihydro-2H-pyrrole	DMRXW3U	Discovery agent	N.A.	Investigative	[64]
2-Hex-5-enyl-5-non-8-enyl-pyrrolidine	DM7KDQV	Discovery agent	N.A.	Investigative	[64]
2-Hex-5-enyl-5-nonyl-pyrrolidine	DMIBRYM	Discovery agent	N.A.	Investigative	[64]
2-morpholino-N-phenethylpyrimidin-4-amine	DMIQYWM	Discovery agent	N.A.	Investigative	[65]
2-Propyl-beta-carboline-2-ium iodide	DMBW6GA	Discovery agent	N.A.	Investigative	[66]
24-ethyl-cholest-7-ene-3,5,6-triol	DMQSTYZ	Discovery agent	N.A.	Investigative	[53]
24-ethylcholest-6-ene-3,5-diol	DMZIQ56	Discovery agent	N.A.	Investigative	[53]
3,4,5,6-Tetrachloro-[1,2]benzoquinone	DMSV6K5	Discovery agent	N.A.	Investigative	[67]
3,6,9,12,15-Pentaoxaheptadecane	DMY8IOP	Discovery agent	N.A.	Investigative	[48]
3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM	DMBIRC6	Discovery agent	N.A.	Investigative	[48]
3-(2,5-Dioxo-pyrrolidin-1-yl)-benzoic acid	DM6JTNW	Discovery agent	N.A.	Investigative	[68]
3-(2-Diethylamino-acetamino)-rutaecarpine	DM08GRF	Discovery agent	N.A.	Investigative	[69]
3-(2-Diethylamino-propionamino)-rutaecarpine	DM1FOIZ	Discovery agent	N.A.	Investigative	[69]
3-(2-N-Piperidyl-acetamino)-rutaecarpine	DM3BQO0	Discovery agent	N.A.	Investigative	[69]
3-(2-N-Piperidyl-propionamino)-rutaecarpine	DMFEHDY	Discovery agent	N.A.	Investigative	[69]
3-(2-N-Pyrrolyl-acetamino)-rutaecarpine	DMQ0A8W	Discovery agent	N.A.	Investigative	[69]
3-(2-N-Pyrrolyl-propionamino)-rutaecarpine	DM9MRTW	Discovery agent	N.A.	Investigative	[69]
3-(3-Carboxy-propionylamino)-benzoic acid	DMSJGQE	Discovery agent	N.A.	Investigative	[68]
3-(4-Benzoylpiperazine-1-carbonyl)coumarin	DMAT7VN	Discovery agent	N.A.	Investigative	[70]
3-(4-o-Tolylpiperazine-1-carbonyl)coumarin	DMIBAM2	Discovery agent	N.A.	Investigative	[70]
3-(4-Phenylpiperazin-1-carbonyl)coumarin	DMH27E0	Discovery agent	N.A.	Investigative	[70]
3-(dimethylamino)phenyl phenylcarbamate	DMM05G2	Discovery agent	N.A.	Investigative	[13]
3-hydroxy-N,N,N-trimethylbenzenaminium iodide	DMXO98C	Discovery agent	N.A.	Investigative	[71]
3-[(1s)-1-(Dimethylamino)Ethyl]Phenol	DM2KXFS	Discovery agent	N.A.	Investigative	[48]
3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-1H-indazole	DME1UNY	Discovery agent	N.A.	Investigative	[34]
3-[3-(benzylmethylamino)propoxy]xanthen-9-one	DMPVXTB	Discovery agent	N.A.	Investigative	[72]
3-[4-(benzylmethylamino)butoxy]xanthen-9-one	DMZPULH	Discovery agent	N.A.	Investigative	[72]
3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one	DMQZ0A7	Discovery agent	N.A.	Investigative	[72]
3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one	DM89RN3	Discovery agent	N.A.	Investigative	[72]
3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one	DMMD3G6	Discovery agent	N.A.	Investigative	[72]
3-[8-(benzylmethylamino)octyloxy]xanthen-9-one	DM31WYF	Discovery agent	N.A.	Investigative	[72]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one	DMM9X0G	Discovery agent	N.A.	Investigative	[73]
4-formylphenyl-O-beta-D-ribopyranoside	DM7DW0G	Discovery agent	N.A.	Investigative	[74]
4-formylphenyl-O-beta-Dglucopyranoside	DM1VNEF	Discovery agent	N.A.	Investigative	[74]
4-ISOPROPYLPHENSERINE	DMMDGR2	Discovery agent	N.A.	Investigative	[75]
4-[4-(benzhydryloxy)piperidino]butyl benzoate	DM5Z64L	Discovery agent	N.A.	Investigative	[76]
4ALPHA-(HYDROXYMETHYL)-4ALPHA-DEMETHYLTERRITREM B	DMGYK25	Discovery agent	N.A.	Investigative	[77]
5,6-dinitroacenaphthoquinone	DM07HYA	Discovery agent	N.A.	Investigative	[57]
5-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine	DMTJNY0	Discovery agent	N.A.	Investigative	[78]
5-Hex-5-enyl-2-nonyl-3,4-dihydro-2H-pyrrole	DMHGQRF	Discovery agent	N.A.	Investigative	[64]
6,8-Dichloro-1,2,3,4-tetrahydro-acridin-9-ylamine	DMUEFDM	Discovery agent	N.A.	Investigative	[79]
6-chlorotacrine hydrochloride	DMV0C69	Discovery agent	N.A.	Investigative	[80]
6-hydroxy-1,2,9-trimethyl-9H-beta-carbolin-2-ium	DMWLN2Y	Discovery agent	N.A.	Investigative	[81]
6-hydroxy-1,2-dimethyl-9H-beta-carbolin-2-ium	DM20DAG	Discovery agent	N.A.	Investigative	[81]
6-hydroxy-2,9-dimethyl-9H-beta-carbolin-2-ium	DMNA2M6	Discovery agent	N.A.	Investigative	[81]
6-hydroxy-2-methyl-9H-beta-carbolin-2-ium	DMAK35M	Discovery agent	N.A.	Investigative	[81]
6-methoxy-1,2-dimethyl-9H-beta-carbolin-2-ium	DMJUT70	Discovery agent	N.A.	Investigative	[81]
6-methoxy-1,9-dimethyl-9H-pyrido[3,4-b]indole	DMOHWPD	Discovery agent	N.A.	Investigative	[81]
6-methoxy-2,9-dimethyl-9H-beta-carbolin-2-ium	DMG3F7D	Discovery agent	N.A.	Investigative	[81]
6-methoxy-2-methyl-9H-beta-carbolin-2-ium	DMHITF8	Discovery agent	N.A.	Investigative	[81]
6-Methyl-4-(4-benzoylpiperazin-1-yl)coumarin	DMOVUP2	Discovery agent	N.A.	Investigative	[70]
6-Methyl-4-(4-o-tolylpiperazin-1-yl)coumarin	DMN0SYW	Discovery agent	N.A.	Investigative	[70]
6-Methyl-4-(4-phenylpiperazin-1-yl)coumarin	DMU7E3O	Discovery agent	N.A.	Investigative	[70]
7-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine	DM1SEXA	Discovery agent	N.A.	Investigative	[78]
7-Oxo-7H-dibenzo[de,g]quinoline	DMJZR0A	Discovery agent	N.A.	Investigative	[82]
8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine	DMS7DA3	Discovery agent	N.A.	Investigative	[78]
9-Amino-1,2,3,4-tetrahydro-acridine-1,7-diol	DMNHZFG	Discovery agent	N.A.	Investigative	[30]
9-amino-7H-dibenzo[de,h]quinolin-7-one	DMNMVCZ	Discovery agent	N.A.	Investigative	[82]
9-Ethyl-2-methyl-beta-carboline-2-ium iodide	DM70MPJ	Discovery agent	N.A.	Investigative	[66]
9-Ethyl-beta-carboline	DMHKUO9	Discovery agent	N.A.	Investigative	[66]
9-hydrazino-1,2,3,4-tetrahydroacridine	DMOX21P	Discovery agent	N.A.	Investigative	[83]
9-O-[2-(Phenylol-1-yloxy)ethyl]berberine bromide	DMYXEJ8	Discovery agent	N.A.	Investigative	[84]
9-O-[2-(Phenylol-1-yloxy)hexyl]berberine bromide	DM081G2	Discovery agent	N.A.	Investigative	[84]
9-O-[3-(2-Pyridinoxyl)butyl]-berberine bromide	DMHRV2A	Discovery agent	N.A.	Investigative	[56]
9-O-[3-(4-Bromo-phenoxyl)butyl]-berberine bromide	DM4JG9S	Discovery agent	N.A.	Investigative	[56]
9-O-[3-(4-Nitro-phenoxyl)butyl]-berberine bromide	DMWVSPH	Discovery agent	N.A.	Investigative	[56]
9-O-[3-(Phenylamino)propyl]-berberine bromide	DMKPUWX	Discovery agent	N.A.	Investigative	[56]
9-O-[3-(Phenylol-1-yloxy)propyl]berberine bromide	DM0FNUX	Discovery agent	N.A.	Investigative	[84]
9-O-[4-(Phenylol-1-yloxy)butyl]berberine bromide	DM58XF6	Discovery agent	N.A.	Investigative	[84]
9-O-[5-(Phenylol-1-yloxy)pentyl]berberine bromide	DMPZTG9	Discovery agent	N.A.	Investigative	[84]
Allyl-trimethyl-ammonium	DM1VHCL	Discovery agent	N.A.	Investigative	[52]
AP-2238	DMQWIEL	Discovery agent	N.A.	Investigative	[85]
AP-2243	DMRYL9X	Discovery agent	N.A.	Investigative	[86]
BENZOQUINONE	DMNBA0G	Discovery agent	N.A.	Investigative	[67]
Beta-L-fucose	DM3BOQA	Discovery agent	N.A.	Investigative	[87]
BIS(12)-HUPERZINE B	DMWAS4Q	Discovery agent	N.A.	Investigative	[88]
Bis(14)-Huperzine B	DM58YDV	Discovery agent	N.A.	Investigative	[88]
BIS(16)-HUPERZINE B	DMYQM3B	Discovery agent	N.A.	Investigative	[88]
BIS(18)-HUPERZINE B	DM3W1T4	Discovery agent	N.A.	Investigative	[88]
BIS(20)-HUPERZINE B	DMHQKCJ	Discovery agent	N.A.	Investigative	[88]
BIS(8)-HUPERZINE B	DMER5GT	Discovery agent	N.A.	Investigative	[88]
BIS(9)-HUPERZINE B	DM5WFQM	Discovery agent	N.A.	Investigative	[88]
Bis-7-tacrine	DMVNC1R	Discovery agent	N.A.	Investigative	[65]
But-3-enyl-trimethyl-ammonium bromide	DMMHGIN	Discovery agent	N.A.	Investigative	[52]
BW284C51	DMQ3AC0	Discovery agent	N.A.	Investigative	[89]
BZYX	DMA0GSY	Neurodegenerative disorder	8A20-8A23	Investigative	[1]
CAPROCTAMINE	DMDZE8N	Discovery agent	N.A.	Investigative	[90]
Carinatumins B (2)	DMUSGYQ	Discovery agent	N.A.	Investigative	[91]
CHF-2819	DMLJGVX	Discovery agent	N.A.	Investigative	[92]
CHLORANIL	DMCHGF1	Discovery agent	N.A.	Investigative	[67]
Chlorphrifos oxon	DMGBT68	Discovery agent	N.A.	Investigative	[93]
CHLORPYRIFOS	DMKPUI6	Discovery agent	N.A.	Investigative	[94]
CHOLINE IODIDE	DMW6U7K	Discovery agent	N.A.	Investigative	[52]
Cis-2,6-dimethyl-1-methyl sulfonyl piperidine	DMJ3HG9	Discovery agent	N.A.	Investigative	[60]
CLEBOPRIDE	DMTLOU6	Discovery agent	N.A.	Investigative	[58]
CORONARIDINE	DMZBUE7	Discovery agent	N.A.	Investigative	[95]
CP-126998	DM3ZIDT	Discovery agent	N.A.	Investigative	[96]
CRYPTADINE B	DM92IK8	Discovery agent	N.A.	Investigative	[97]
DECIDIUM	DM4SWYX	Discovery agent	N.A.	Investigative	[51]
Dimethyl-pent-4-enyl-ammonium bromide	DMO0UI8	Discovery agent	N.A.	Investigative	[52]
Ethyl octylfluorophosphonate	DMXMRK7	Discovery agent	N.A.	Investigative	[93]
ETHYLPHENSERINE	DMT51QD	Discovery agent	N.A.	Investigative	[98]
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[63]
Galanthamine derivative	DMAFE24	Discovery agent	N.A.	Investigative	[51]
GANSTIGMINE	DMFT4GU	Discovery agent	N.A.	Investigative	[51]
GENESERINE	DMAUFLQ	Discovery agent	N.A.	Investigative	[92]
HALOXYSTEROL A	DM4AEGQ	Discovery agent	N.A.	Investigative	[53]
HALOXYSTEROL B	DMD8O7S	Discovery agent	N.A.	Investigative	[53]
Haloxysterol C	DMU1DHM	Discovery agent	N.A.	Investigative	[53]
Haloxysterol D	DMWCZLT	Discovery agent	N.A.	Investigative	[53]
Hexyl-trimethyl-ammonium	DM9EW7V	Discovery agent	N.A.	Investigative	[52]
Huprine X	DMTPXB6	Discovery agent	N.A.	Investigative	[51]
Huprine Y	DMYH0XQ	N. A.	N. A.	Investigative	[99]
Huprine-Tacrine Heterodimer	DMJ4ME7	Discovery agent	N.A.	Investigative	[100]
Infractopicrin	DMV6UJ5	Discovery agent	N.A.	Investigative	[61]
Iso-OMPA	DMFX16H	Discovery agent	N.A.	Investigative	[101]
Isopropyl dodecylfluorophosphonate	DML54EA	Discovery agent	N.A.	Investigative	[93]
Isosorbide-2-(methylcarbamate)-5-benzoate	DMC7MLN	Discovery agent	N.A.	Investigative	[101]
Isosorbide-2-(methylcarbamate)-5-mononitrate	DMEKMOF	Discovery agent	N.A.	Investigative	[101]
Isosorbide-2-benzylcarbamate-5-cyclopentanoate	DMWDQ90	Discovery agent	N.A.	Investigative	[101]
Isosorbide-2-benzylcarbamate-5-cyclopropanoate	DM8E2L6	Discovery agent	N.A.	Investigative	[101]
Isosorbide-2-benzylcarbamate-5-tosylate	DMCHSWQ	Discovery agent	N.A.	Investigative	[101]
Isosorbide-di-(4-nitrophenyl carbamate)	DMPA2ON	Discovery agent	N.A.	Investigative	[102]
Isosorbide-di-(benzylcarbamate)	DMFVN71	Discovery agent	N.A.	Investigative	[102]
Isosorbide-di-(ethylcarbamate)	DMTHWXO	Discovery agent	N.A.	Investigative	[102]
Isosorbide-di-phenylcarbamate	DMT1ZGM	Discovery agent	N.A.	Investigative	[102]
LAWSARITOL	DM5GNFO	Discovery agent	N.A.	Investigative	[53]
LIPOCRINE	DMUIVCX	Discovery agent	N.A.	Investigative	[103]
LYSICAMINE	DMIZQW6	Discovery agent	N.A.	Investigative	[104]
MEMOQUIN	DM9S30P	Discovery agent	N.A.	Investigative	[103]
MESUAGENIN A	DMZ12GE	Discovery agent	N.A.	Investigative	[105]
MESUAGENIN B	DMKXG3V	Discovery agent	N.A.	Investigative	[105]
Mesuagenin D	DMLZGO7	Discovery agent	N.A.	Investigative	[105]
Methyl Phosphinic Acid	DM096SI	Discovery agent	N.A.	Investigative	[63]
MMB-4	DMUL4PE	Poison intoxication	NE6Z	Investigative	[1]
Monoisopropylphosphorylserine	DM0OFT6	Discovery agent	N.A.	Investigative	[63]
N,N'-(1',10'-decylene)-bis-(-)-nor-MEP	DMIX0CT	Discovery agent	N.A.	Investigative	[106]
N,N'-(1',11'-undecydene)-bis-(-)-nor-MEP	DM5NVIO	Discovery agent	N.A.	Investigative	[106]
N,N'-(1',12'-dodecydene)-bis-(-)-nor-MEP	DMWI06H	Discovery agent	N.A.	Investigative	[106]
N,N'-(1',5'-pentylene)-bis-(-)-nor-MEP	DMBPC0K	Discovery agent	N.A.	Investigative	[106]
N,N'-(1',6-hexylene)-bis-(-)-nor-MEP	DMU4BIW	Discovery agent	N.A.	Investigative	[106]
N,N'-(1',7'-heptylene)-bis-(-)-nor-MEP	DMSORHA	Discovery agent	N.A.	Investigative	[106]
N,N'-(1',8'-octylene)-bis-(-)-nor-MEP	DMHFYK2	Discovery agent	N.A.	Investigative	[106]
N,N'-(1',9'-nonylene)-bis-(-)-nor-MEP	DMIWF7U	Discovery agent	N.A.	Investigative	[106]
N-(14-methylallyl)norgalanthamine	DMW460V	Discovery agent	N.A.	Investigative	[107]
N-ALLYLNORGALANTHAMINE	DMRXA8N	Discovery agent	N.A.	Investigative	[107]
N-allylnorlitebamine	DM5W2VK	Discovery agent	N.A.	Investigative	[108]
N-benzyl-2-(pyrrolidin-1-yl)pyrimidin-4-amine	DM0ZXBQ	Discovery agent	N.A.	Investigative	[65]
N-benzyl-2-morpholinopyrimidin-4-amine	DMQCGFL	Discovery agent	N.A.	Investigative	[65]
N-benzyl-2-thiomorpholinopyrimidin-4-amine	DMRJMGK	Discovery agent	N.A.	Investigative	[65]
N-benzylnorlitebamine	DMVEZH1	Discovery agent	N.A.	Investigative	[108]
N-butylnorlitebamine	DMNFTO6	Discovery agent	N.A.	Investigative	[108]
N-isobutylnorlitebamine	DM9Z6VP	Discovery agent	N.A.	Investigative	[108]
N-isopropylnorlitebamine	DMG8NB0	Discovery agent	N.A.	Investigative	[108]
N-isopropylnorlitebamineN-methoiodide	DMDVO9T	Discovery agent	N.A.	Investigative	[108]
N-Methyl-1'H-phenothiazine-1'-carboxamide	DMK8VZM	Discovery agent	N.A.	Investigative	[109]
N-n-dodecyl-7-methoxytacrine hydrochloride	DM8FOSR	Discovery agent	N.A.	Investigative	[42]
N-n-heptyl-7-methoxytacrine hydrochloride	DMA8R47	Discovery agent	N.A.	Investigative	[42]
N-n-hexyl-7-methoxytacrine hydrochloride	DM4ZMG6	Discovery agent	N.A.	Investigative	[42]
N-n-nonyl-7-methoxytacrine hydrochloride	DMLH23M	Discovery agent	N.A.	Investigative	[42]
N-n-octyl-7-methoxytacrine hydrochloride	DMLC257	Discovery agent	N.A.	Investigative	[42]
N-n-pentyl-7-methoxytacrine hydrochloride	DMWAK5V	Discovery agent	N.A.	Investigative	[42]
N-n-propyl-7-methoxytacrine hydrochloride	DMCN78A	Discovery agent	N.A.	Investigative	[42]
N-phenethyl-2-(pyrrolidin-1-yl)pyrimidin-4-amine	DMJQZMH	Discovery agent	N.A.	Investigative	[65]
N-propylnorlitebamine	DM3JQYD	Discovery agent	N.A.	Investigative	[108]
NPRx-30	DMYB2EZ	Neurodegenerative disorder	8A20-8A23	Investigative	[1]
NSC-23180	DMJ91Y7	Discovery agent	N.A.	Investigative	[57]
OBIDOXIME	DMM98BC	Discovery agent	N.A.	Investigative	[94]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[93]
Petrosamine	DMYIEOJ	Discovery agent	N.A.	Investigative	[110]
Propidium	DMZ1FRS	Discovery agent	N.A.	Investigative	[63]
Pseudocolumbamine trifluoroacetate	DM0E5G9	Discovery agent	N.A.	Investigative	[104]
Pseudopalmatine trifluoroacetate	DM4HE1V	Discovery agent	N.A.	Investigative	[104]
TACRINE(8)-4-AMINOQUINOLINE	DMOWHER	Discovery agent	N.A.	Investigative	[48]
TASPINE	DM9S5DV	Discovery agent	N.A.	Investigative	[111]
TERRITREM B	DMPX7QS	Discovery agent	N.A.	Investigative	[112]
Tetraethylene Glycol	DMH4AGL	Discovery agent	N.A.	Investigative	[63]
THIOCTIC ACID	DMNFCXW	Discovery agent	N.A.	Investigative	[113]
TOLSERINE	DMPTM6V	Discovery agent	N.A.	Investigative	[98]
TRIMEDOXIME	DMPXHTY	Discovery agent	N.A.	Investigative	[94]
Trimethyl-(3-nitro-phenyl)-ammonium iodide	DMQXPMB	Discovery agent	N.A.	Investigative	[52]
Trimethyl-(4-oxo-pentyl)-ammonium iodide	DMJ4I98	Discovery agent	N.A.	Investigative	[52]
TURBINATINE	DMLDYVB	Discovery agent	N.A.	Investigative	[114]
Voacangine	DMA106W	Discovery agent	N.A.	Investigative	[95]
XANTHOSTIGMINE	DM38TLN	Discovery agent	N.A.	Investigative	[115]
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⏷ Show the Full List of 220 Investigative Drug(s)

Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This DTT

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Parkinson's disease	8A00.0	Substantia nigra tissue	6.39E-02	-1.07	-1.15
Alzheimer's disease	8A00.0	Entorhinal cortex	2.73E-04	-0.16	-0.54
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The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name

Acetylcholinesterase (ACHE) DME Info

Gene Name

ACHE

2 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[116]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[117]
------------------------------------------------------------------------------------

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