Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMBJXCF)

Drug Name
2pyrrolidin-1-yl-1-phenylpentan-1-one Drug Info
Synonyms
14530-33-7; alpha-PVP; 1-Phenyl-2-(pyrrolidin-1-yl)pentan-1-one; alpha-pyrrolidinovalerophenone; Desmethyl pyrovalerone; Alpha-Pyrrolidinopentiophenone; CHEMBL205082; 1-Pentanone, 1-phenyl-2-(1-pyrrolidinyl)-; Flakka; beta-Ketone-prolintane; Prolintanone; Gravel; beta-Keto-prolintane; a-PVP; 2pyrrolidin-1-yl-1-phenylpentan-1-one; 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone; a-Pyrrolidinopentiophenone; O-2387; SCHEMBL4936204; DTXSID70456954; YDIIDRWHPFMLGR-UHFFFAOYSA-N; MFCD24386810; BDBM50182584; alpha-Pyrrolidinopentiophenone, a-PVP
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11148955
CAS Number
CAS 14530-33-7
TTD Drug ID
DMBJXCF

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine transporter (DAT) TTVBI8W SC6A3_HUMAN Inhibitor [1]
Norepinephrine transporter (NET) TTAWNKZ SC6A2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Dopamine transporter (DAT) DTT SLC6A3 4 2.609 5.233 3.7
Norepinephrine transporter (NET) DTT SLC6A2 2.459 3.426 3.322 3.35
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dopamine transporter (DAT) DTT SLC6A3 1.08E-03 -3.08 -1.99
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32.