Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMBMYKQ)

Drug Name
PMID22564207C25b Drug Info
Synonyms CEP-28122; 1022958-60-6; GTPL8139; EX-A1541; ZINC84654307; BDBM50389154; CS-5176; NCGC00387821-03; HY-18030
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
57325421
CAS Number
CAS 1431697-87-8
TTD Drug ID
DMBMYKQ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ALK tyrosine kinase receptor (ALK) TTPMQSO ALK_HUMAN Inhibitor [1]
Omphalocele kinase 1 (NUAK1) TT65FL0 NUAK1_HUMAN Inhibitor [1]
Proto-oncogene c-Fer (FER) TTRA9G0 FER_HUMAN Inhibitor [1]
Proto-oncogene c-Fes (FES) TTLBY21 FES_HUMAN Inhibitor [1]
Ribosomal protein S6 kinase alpha-2 (RSK2) TT0ZW9O KS6A2_HUMAN Inhibitor [1]
Ribosomal protein S6 kinase alpha-3 (RSK3) TTUM2ZR KS6A3_HUMAN Inhibitor [1]
Ribosomal protein S6 kinase alpha-6 (RSK6) TT3KYWB KS6A6_HUMAN Inhibitor [1]
Serine/threonine-protein kinase Chk2 (RAD53) TT9ABMF CHK2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
ALK tyrosine kinase receptor (ALK) DTT ALK 5.329 3.897 4.178 4.943
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
ALK tyrosine kinase receptor (ALK) DTT ALK 7.19E-15 0.18 0.61
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase. J Med Chem. 2012 May 24;55(10):4580-93.