Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMBQ0TY)

Drug Name

N,N-bis(cyanomethyl)-3,4-dimethoxybenzamide Drug Info

Synonyms

N,N-bis(cyanomethyl)-3,4-dimethoxybenzamide; AC1LDLXQ; Cambridge id 5654537; Oprea1_349431; CHEMBL244919; ZINC29912; BDBM23727; MolPort-001-507-799; HMS1584M04; STK002684; AKOS003266947; MCULE-7184403963; ST042963; N,N-bis(cyanomethyl)-3,4-dimethoxybenzamide, 11; SR-01000215998; N~1~,N~1~-bis(cyanomethyl)-3,4-dimethoxybenzamide; SR-01000215998-1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 669334
TTD Drug ID: DMBQ0TY

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neutrophil elastase (NE)	TTPLTSQ	ELNE_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Neutrophil elastase (NE)	DTT	ELANE	2.379	2.036	1.379	2.945

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Neutrophil elastase (NE)	DTT	ELANE	2.35E-01	-0.55	-0.82

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38.