Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCDZ8A)

Drug Name
(S)-2-amino-2-p-tolylacetic acid Drug Info
Synonyms
119615-71-3; CHEMBL378582; (S)-2-Amino-2-(p-tolyl)acetic acid; (2S)-2-amino-2-(4-methylphenyl)acetic acid; (S)-2-amino-2-p-tolylacetic acid; AC1ODTRS; 4-Methyl-L-phenylglycine; (S)-Amino-p-tolyl-acetic acid; SCHEMBL11728987; DTXSID20427275; ZINC2567159; BENZENEACETIC ACID, ALPHA-AMINO-4-METHYL-, (ALPHAS)- (9CI); BDBM50179719; AKOS006275863; (2S)-Amino(4-methylphenyl)acetic acid; AJ-41354; KB-276738; AB1006787; Benzeneacetic acid, a-amino-4-methyl-, (aS)-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
7020729
CAS Number
CAS 119615-71-3
TTD Drug ID
DMCDZ8A

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) TTFK1JQ CA2D1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 5.083 4.833 5.343 2.536
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 9.36E-01 -0.03 -0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 2.81E-05 -0.15 -0.68
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.