Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCH3G5)

Drug Name
AQX-1125 Drug Info
Synonyms AQX-108; AQX-131; AQX-132; AQX-133; AQX-134; AQX-135; AQX-140; AQX-150; SHIP agonists (cancer/inflammation), Aquinox
Indication
Disease Entry ICD 11 Status REF
Chronic obstructive pulmonary disease CA22 Phase 2 [1]
Cross-matching ID
PubChem CID
76965484
CAS Number
CAS 782487-28-9
TTD Drug ID
DMCH3G5

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
SH2 domain inositol 5'-phosphatase 1 (INPP5D) TTTP2Z1 SHIP1_HUMAN Agonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
SH2 domain inositol 5'-phosphatase 1 (INPP5D) DTT INPP5D 6.074 6.277 6.145 6.753
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 12 Disease of the respiratory system
Disease Class ICD-11: CA23 Asthma
The Studied Tissue Lung tissue
The Studied Disease Chronic obstructive pulmonary disease [ICD-11:CA23]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
SH2 domain inositol 5'-phosphatase 1 (INPP5D) DTT INPP5D 9.59E-01 -0.03 -0.1
SH2 domain inositol 5'-phosphatase 1 (INPP5D) DTT INPP5D 5.30E-06 0.24 0.92
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT02324972) Pilot Efficacy and Safety Study of AQX-1125 in Atopic Dermatitis. U.S. National Institutes of Health.
2 Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo. Br J Pharmacol. 2013 Mar;168(6):1519-29.