Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCNBHY)

Drug Name
JNJ-42905343 Drug Info
Indication
Disease Entry ICD 11 Status REF
Anaemia 3A90 Preclinical [1]
Iron deficiency 5B5K.0 Preclinical [1]
Cross-matching ID
TTD Drug ID
DMCNBHY

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HIF-prolyl hydroxylase (HPH) TTJQFBG NOUNIPROTAC Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
HIF-prolyl hydroxylase (HPH) DTT HPH 6.61 7.198 6.148 6.784
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Anaemia
ICD Disease Classification 3A90
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
HIF-prolyl hydroxylase (HPH) DTT NO-GeName 7.70E-01 4.40E-03 0.02
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov. 2017 Jun;16(6):400-423.
2 Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats. Br J Pharmacol. 2015 Aug;172(16):4078-88.