Details of the Drug

General Information of Drug (ID: DMCNBHY)

Drug Name
JNJ-42905343
Indication
Disease Entry ICD 11 Status REF
Anaemia 3A90 Preclinical [1]
Iron deficiency 5B5K.0 Preclinical [1]
Drug Type
Small molecular drug
Cross-matching ID
TTD ID
D6VLX2
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HIF-prolyl hydroxylase (HPH) TTJQFBG NOUNIPROTAC Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Anaemia
ICD Disease Classification 3A90
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
HIF-prolyl hydroxylase (HPH) DTT NO-GeName 7.70E-01 4.40E-03 0.02
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov. 2017 Jun;16(6):400-423.
2 Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats. Br J Pharmacol. 2015 Aug;172(16):4078-88.