Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCQRS2)

Drug Name
RG7414 Drug Info
Indication
Disease Entry ICD 11 Status REF
Colorectal cancer 2B91.Z Discontinued in Phase 2 [1]
Non-small-cell lung cancer 2C25.Y Discontinued in Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMCQRS2

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor-like protein 7 (EGFL7) TT7WD0H EGFL7_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Epidermal growth factor-like protein 7 (EGFL7) DTT EGFL7 6.632 5.514 4.907 6.053
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Colorectal cancer
ICD Disease Classification 2B91.Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Epidermal growth factor-like protein 7 (EGFL7) DTT EGFL7 2.56E-01 0.07 0.33
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030998)
2 Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy. J Clin Invest. 2013 September 3; 123(9): 3997-4009.