Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCZAJW)

Drug Name
Garnocestim Drug Info
Synonyms SB-251353
Indication
Disease Entry ICD 11 Status REF
Bone marrow transplantation QB63.6 Discontinued in Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMCZAJW

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
C-X-C chemokine receptor type 4 (CXCR4) TTBID49 CXCR4_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
C-X-C chemokine receptor type 4 (CXCR4) DTT CXCR4 7.415 8.304 6.284 6.972
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Bone marrow transplantation
ICD Disease Classification QB63.6
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
C-X-C chemokine receptor type 4 (CXCR4) DTT CXCR4 7.10E-15 -0.4 -0.69
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010770)
2 CN patent application no. 101094684, With the combination of chemokine activation progenitor cells/stem cells.