Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMD1VZL)

Drug Name

Pemafibrate Drug Info

Synonyms

K-877

Indication

Disease Entry	ICD 11	Status	REF
Hyperlipidemia	5C80.Z	Approved	[1]
Cardiovascular disease	BA00-BE2Z	Phase 3	[2]
Lipid metabolism disorder	5C52.Z	Phase 3	[3]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Peroxisome proliferator-activated receptor alpha (PPARA)	TTJ584C	PPARA_HUMAN	Agonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Peroxisome proliferator-activated receptor alpha (PPARA)	DTT	PPARA	4.65	4.138	4.564	5.031

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Hyperlipidemia

ICD Disease Classification

5C80.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Peroxisome proliferator-activated receptor alpha (PPARA)	DTT	PPARA	1.74E-01	-0.17	-0.3

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Pemafibrate: First Global Approval. Drugs. 2017 Oct;77(16):1805-1810.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032781)