Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMD5YKO)

Drug Name
3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione Drug Info
Synonyms CHEMBL29863; 3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
13660218
TTD Drug ID
DMD5YKO

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aromatase (CYP19A1) TTSZLWK CP19A_HUMAN Inhibitor [1]
Cholesterol desmolase (CYP11A1) TTSYVO6 CP11A_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Cholesterol desmolase (CYP11A1) DTT CYP11A1 5.409 4.385 5.19 5.6
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cholesterol desmolase (CYP11A1) DTT CYP11A1 1.09E-47 -0.41 -1.12
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. J Med Chem. 1986 Aug;29(8):1362-9.